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|Product Name:||Follistatin 344;FST344 , FS, Activin-binding Protein.||CAS:||307297-39-8|
|Molecular Formula:||C14H22N4O9||Molecular Weight:||390|
|Standard:||Pharmaceutical Grade||Shipping Choice:||By Express , EMS ,EUB ,ETK ,HKEMS ,UPS ,Fedex ,DHL ,TNT|
No Side Effect Human Growth Peptides Follistatin 344 White Lyophilized Powder FST 344 For Muscle Growth
Epitalon Qiuck Details :
Name: Follistatin 344
Follistatin 344 Synonyms: FST344 , FS, Activin-binding protein.
Follistatin 344 Appearance: Sterile Filtered White Lyophilized (Freeze-Dried)
Follistatin 344 Manufacturer: Huao
Follistatin 344 Purity (by HPLC): 99.00%
Follistatin 344 Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Follistatin 344 Formulation: Lyophilized from a concentrated (1mg / ml) solution containing no additives.
Solubility: It is recommended to reconstitute the lyophilized Follistatin in sterile 18Mg-cm H2O not less than 100mg / ml, which can then be further diluted to other aqueous solutions.
Stability: Lyophilized Follistatin although stable at room temperature for 3 weeks.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Buffer Before Lyophilized: PBS, PH7.4, 4M urea, 300mM Mannitol
Volume Before Lyophilized:500ul
Purity:85% by SDS-PAGE
Packing: 1mg / vial
Follistatin 344 Description:
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal, bone marrow, and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin, the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist.
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The monkey-based study has led to the hypothesis that the inclusion of Follistatin 344 into the process of gene therapy could contain several potentially positive ramifications in relation to a host of muscle-related ailments. Studies in this field are particularly focused on the ways in which the peptide could theoretically aid in the treatment of muscular dystrophy. This particular condition is representative of several muscle diseases that have been shown to weaken the musculoskeletal system, which in turn has a negative impact on mobility. Some of these diseases include Becker muscular dystrophy, Duchenne muscular dystrophy, Limb-girdle muscular dystrophy, and myotonic muscular dystrophy. The diseases are characterized by defects in muscle proteins, progressive skeletal muscle weakness, and the death of muscular cells and muscular tissue. It is thought that the presence of Follistatin 344 could aid in replenishing strength levels to the affected muscles, which in turn could reverse the negative effects of the condition.
Follistatin 344 used for Muscle Growth :
Follistatin works by binding to and inhibiting transforming growth factor-β (TGF-β) peptides such as myostatin which is responsible for regulating and limiting muscle growth. It’s also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow.
In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH). High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function. However, FSH levels that are too low can also negatively impact health and reproductive capabilities.
Administering FS344 via a small virus (re: adeno-associated virus/AAV) can increase muscle size and strength in animal species ranging from mice to monkeys with no significant adverse effects on organs, reproductive capabilities, serum estradiol (re: primary female sex hormone), luteinizing hormone (LH), and FSH levels. When scientists administered follistatin in mice with spinal muscular atrophy, the mice experienced increased muscle mass, improved motor function, and a 30% longer lifespan compared to mice in the control group.
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