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99.8% Inhibitor API Pharmaceutical Raw Material Powder Regorafenib With Anhydrous CAS 755037 03 7

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99.8% Inhibitor API Pharmaceutical Raw Material Powder Regorafenib With Anhydrous CAS 755037 03 7

China 99.8% Inhibitor API Pharmaceutical Raw Material Powder Regorafenib With Anhydrous CAS 755037 03 7 supplier
99.8% Inhibitor API Pharmaceutical Raw Material Powder Regorafenib With Anhydrous CAS 755037 03 7 supplier 99.8% Inhibitor API Pharmaceutical Raw Material Powder Regorafenib With Anhydrous CAS 755037 03 7 supplier 99.8% Inhibitor API Pharmaceutical Raw Material Powder Regorafenib With Anhydrous CAS 755037 03 7 supplier 99.8% Inhibitor API Pharmaceutical Raw Material Powder Regorafenib With Anhydrous CAS 755037 03 7 supplier

Large Image :  99.8% Inhibitor API Pharmaceutical Raw Material Powder Regorafenib With Anhydrous CAS 755037 03 7

Product Details:

Place of Origin: China
Brand Name: HW Pharmaceutical Raw Material
Certification: GMP,SGS,UKAS,ISO
Model Number: CAS: 755037-03-7 Pharmaceutical Raw Material

Payment & Shipping Terms:

Minimum Order Quantity: Negotiable
Price: Negotiable
Packaging Details: foil bag or as your requirement
Delivery Time: Within 1-2 working days upon receipt payment
Payment Terms: T/T, Western union, MoneyGram
Supply Ability: 1000kgs/month
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Detailed Product Description
CAS: 755037-03-7 Grade: USP/BP
Assay: 99% MF: C21H15ClF4N4O3
MW: 482.8154128 Character: White Powder
Name: Regorafenib Alias: Regorafenib
Keywords: China Pharmaceutical Raw Materials, China Pharmaceutical Raw Materials Manufacturers, Pharmaceutical Raw Materials Catalog, Pharmaceutical Raw Materials

99.8% Inhibitor API Pharmaceutical Raw Material Powder Regorafenib with Anhydrous CAS 755037-03-7

 

Quick detail

Regorafenib
Regorafenib Synonyms: Regorafenib
Regorafenib CAS: 755037-03-7
Regorafenib MF: C21H15ClF4N4O3
Regorafenib MW: 482.8154128
Appearance : White powders
Usage It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.
Usage BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.
Usage Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively

Product Description

Regorafenib (BAY 73-4506, commercial name Stivarga) is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Since 2009 it was studied as a potential treatment option in multiple tumor types. By 2015 it had 2 US approvals for advanced cancers.

Applications/Usage

For the migration assay, PLC/PRF/5 cells were treated with the drugs and microscopically analyzed at the time of the scratch (T0) and after 48 and 72 hours. For the invasion assay, invading PLC/PRF/5 cells were treated with different drug concentrations (0.5, 1, 2.5 and 5 μM). Invasion was calculated as a percentage of the invading drug-treated cells compared to drug-untreated control cells. Regorafenib inhibited HCC cell migration in both AFP-positive and AFP-negative cells at the same low concentration range as inhibited AFP levels. Similar results were found in a cell invasion assay, at almost identical drug concentrations.

1. It inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent.

2. BAY 73-4506 (Regorafenib) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf.

3. Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively

 

4. Regorafenib is used to treat cancer of the colon and rectum which has spread to other parts of the body. It is also used to treat a certain cancer of the digestive system (gastrointestinal stromal tumor). It works by slowing or stopping the growth of cancer cells.

 

The quality control process

1) Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.

2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.

3) Producing

a) Each operator must do self-inspection of producs and make the corresponding inspection records.
b) Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.

4) Before selling
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.

OUR ADWANTAGE:

High quality with competitive price:
1) Standard: Enterprise Standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.

Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.

99.8% Inhibitor API Pharmaceutical Raw Material Powder Regorafenib With Anhydrous CAS 755037 03 7

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